Course Catalog

BCHB 501: Biochemical and Cellular Sciences
The structure and function of macromolecules including enzyme kinetics, thermodynamics, protein folding, membranes, nucleic acids, glycoproteins, signal transduction, and enzymology of DNA replication, recombination and repair. Instructor Permission Only.
4 credits, M. Danielse

BIOL 362: Shaping National Science Policy
Students will learn techniques that shape our nation's science policy. We will start with an introduction to our political system. Then we will examine hardball politics with guest lectures from journalists, lobbyists, and congressional staff. Finally, we will focus on case studies in advocacy and examine how science affects policy at the local and national levels. Students work on one project throughout the semester. They will break into teams, identify a politically hot science-issue, develop a lobbying strategy, and take their issue to Capitol Hill. This course is cross-listed with the Physics Department. Spring. (NB: 1 credit may apply to Biology major)
3 credits, F. Slakey & Elizabeth Turpen, Office of Senator Lugar

BIOL 415: Introduction to Parasites
This is a discussion based course that will introduce students to the wonderful world of protozoan and helminthic parasitic diseases of humans. Topics will include pathogenesis, drug development and host response to infection. The course will also examine how studies of these organisms have led to fundamental insights into the molecular biology, cell biology, biochemistry and genetics of all eukaryotes. Disease pathogenesis and parasite life cycles will be included in the course of these discussions. Students should have had a prior course in cell biology, molecular biology, microbiology or immunology. Students will be responsible for participating in weekly discussions, presenting papers, and evaluating peers. For 2005, registration preference will be given to graduate students. Undergraduate registration will require permission of the instructor. (Course not offered every year, contact instructor for more info.)
2 credits, S. Singer

BIOL 486: Topics in Immunology
The course consists of lectures, reading of the current literature, and group discussions of current topics in immunology. These topics change from year to year as new breakthroughs in immunology develop or students with special interests enroll. Students must have had a course in immunology. (Course not offered every year, contact instructor for more info.)
3 credits, S. Singer

BIST 502: Applied Biostatistics
This course is designed for a more advanced introductory biostatistical theory and application for students pursuing a Ph.D. in fields outside of the Department of Biostatistics, Bioinformatics, and Biomathematics.
This course is cross listed with TBIO-502.
3 credits, R. Slack

BIST 541: Principles of Epidemiology
Epidemiology overview and history; distributions of disease by time, place and person; association and causality; ecological studies; cross-sectional studies and surveys; case-control studies; analysis of case-control studies; types of bias in case-control studies; cohort studies; analysis of cohort studies; bias in cohort studies; population attributable risk; confounding factors; effect modification (interaction); analysis for confounding and interaction; multivariate analysis; sensitivity, specificity and screening; public health practice and prevention; special issues in cancer epidemiology, infectious disease epidemiology and genetic epidemiology. This course includes a discussion session.
4 credits, C. Loffredo

INTH 440: Health, Environmental Issues, and Development
This course introduces the students to the relationship between environmental quality and human health. It focuses on four aspects: the environment as a health conditioning factor; the environmental health impacts of development projects; the construction and management of healthy surroundings; and the technological aspects of the relation between human beings and environmental health.
3 credits, H. Otterstetter

INTH 445: Globalization and Health Care
This course examines economic, social, cultural, environmental, technological and political dimensions of globalization and how they impact on health status, the provision of health care, and international public health. The course will look at what globalization means for both industrialized and developing countries with a focus on opportunities and risks for health. It will also examine in depth the transnational legal frameworks, the international institutions and the civil society players that influence and respond to the globalization process.
3 credits, B. Liese

INTH 444: Global Patterns of Disease
This course reviews and analyzes recent trends in global health, current problems of health, and the influence of economic, population and social trends on health and living conditions in different countries. The student will acquire the basics of descriptive and analytical epidemiology and key health indicators used in international comparisons. This course discusses questions raised by the World Health Organization's World Health Report 1998: Will the world continue to grow healthier in the 21st century, with more diseases conquered by scientific advances and life expectancy extending ever longer, or will new diseases, failing drugs, poverty, and socioeconomic gaps cancel out these gains? How does the health situation of the U.S. compare with other countries? How can the health situation of the population in developed and underdeveloped countries be improved? Looking at major determinants of health and disease in different national contexts, the student will analyze the main transnational factors that influence the transfer of risks to health and the structural conditions that determine one country's vulnerability in a globalized economy.
3 Credits, J. Teruel

INTH 449: Health in Conflicts, Crises, Disasters
This new course will provide an opportunity for students to become acquainted with the problems related to emergencies and crisis situations and the methods used for preparedness, mitigation and cooperation among countries. Natural or manmade disasters, wars and conflicts, produce situations of emergency with high impact on the life of exposed population groups. There is a disruption of life conditions and the health of the people is, most of the time, immediately affected. There is substantial information on the causes, history, frequency, duration and consequences of the most important disasters, crisis and conflicts in the world, as well as the responses of local, national and international agencies and governments and the mistakes, accidents and lessons learned. Students will analyze information from historical and recent crises, emergencies and disasters using special reading material, videotapes of cases and simulations.
3 credits, J. Teruel

LAW 364: Public Health Law and Ethics
This course is intended to provoke thought and legal and ethical debate over pressing public policy issues surrounding the major health problems facing America— e.g., infectious diseases, smoking, violence, injuries, and the environment. First, the course will examine the foundations of public health law in America. This section will discuss the powers and duties of government to assure the conditions for a healthy population. Second, the course will examine the conflicts between public health and civil liberties. For example, the course will probe conflicts between: (1) injury and disease surveillance and privacy; (2) labeling and advertising restrictions and free expression; (3) personal control measures (e.g., screening, forced medical treatment and quarantine) and liberty; (4) commercial public health regulation and property rights. Finally, the course will examine the future of public health law in America. This "Future" includes a careful analysis of September 11, 2001 and the problem of bioterrorism. This course should be important for all students considering careers in health law as well as those simply interested in exploring and debating the state of public health in America. It is a particularly unique opportunity for students because of the CDC Collaborating Center on Law & the Public’s Health at Georgetown and Johns Hopkins Universities.
3 credits, L. Gostin

LAW 206: Health Law and Policy
Health law is a vast and expanding field. No single course can survey it all. This course focuses on the organization, financing, and provision of medical care, with an eye toward issues not yet resolved by courts, legislators, regulators, and American society. It also considers some related ethical questions. Topics and themes include the economics of health insurance and managed care, regulatory responses to the market's perceived failures, medical tort law, access to care, consumer choice and patient autonomy, defining and assessing quality, health care providers' conflicts of interest, privacy and confidentiality, and socio-economic and racial disparities in health and medical care.
4 credits, M. Bloche

LAW 493: Global Health Law
This course provides an opportunity to closely examine the legal, economic, ethical, and political aspects of global health. The determinates of health (e.g., pathogens, air, food, water, lifestyle choices) do not originate solely within national borders. Health threats inexorably spread to neighboring countries, regions, and even continents. Peoples’ lives are profoundly affected by commerce, politics, science, and technology from all over the world. This course will explore why health hazards seem to change form and migrate everywhere on the earth; why global health and global health law are emerging as central issues of multilateral concern; why extant global governance systems are frequently ineffective; and the strengths and limitations of international law as a tool for improving the health of the world’s population, especially the poorest and most vulnerable. Students will be expected to take a final exam and write a 5 page analysis on an area of importance in global health law.
2 credits, A. Taylor

LAW 183: Health and Human Rights
This seminar provides an opportunity to explore the field of health and human rights. Participants will discuss important problems at the intersection of population health and the human rights of peoples. This seminar examines the interrelationships between modern concepts of public health and international human rights. The first relationship is the impact of health policies, programs, and practices on human rights. A number of illustrative case studies will be used, such as world population control, immunization, and personal control measures for the human immunodeficiency virus, tuberculosis, or emerging diseases. The second relationship is the health impacts resulting from violations of human rights. A number of illustrative case studies will be used such as torture, imprisonment under inhumane conditions, and rape. Special emphasis will be given to the human rights and the health of women. The third relationship is the inextricable linkage between health and human rights. Here, the synergistic relationship between health and human rights will be explored. The seminar will use the International Covenants on Civil and Political Rights, and on Economic, Social and Cultural Rights as the dominant legal instruments in the analysis. We will carefully consider the meaning of the right to health and the material differences between negative and positive rights in international law.
2 credits, B. Berkman

LAW 482: HIV/AIDS in Africa Practicum
This course affords a rare opportunity to conduct cutting-edge research and analysis under Faculty supervision and to brief the preeminent spokesperson on issues related to HIV and AIDS in Africa. During the semester, seminar participants will meet with Faculty members, World Bank Officials, UN Special Envoy Stephen Lewis, Paula Donovan, a specialist in women’s and children’s rights issues and Gerry Caplan, an expert on African politics and history.

The AIDS pandemic has ravaged Africa, creating millions of orphans and exposing a host of discriminatory laws and policies that adversely affect women and children. The pandemic also challenges core notions of law and development and serves as a catalyst for civil and political rights abuses. This course will allow students to explore legal issues raised by the pandemic and to offer information and analysis to the Special Envoy. The Special Envoy will pose research questions to the seminar participants that are likely to focus on women’s and children’s rights, inheritance and property concerns, sexual violence, trade and debt restriction, the role of international financial institutions, user fees and concerns relating to TRIPS. In coordination with the instructor, seminar participants will select and hone a research question. Participants will submit a paper outline for approval during the fourth week of the semester and a draft.

EVALUATION: The seminar will meet weekly. Research questions will be approved by the instructor. Each student will be responsible for producing a minimum 30-page paper (100%) in addition to a three page Executive Summary. Students will workshop their preliminary findings at some point during the second-half of the semester.
3 credits, N. Novogrodsky

LAWJ 369: AIDS Law and Ethics
This course examines the social, legal, political, and ethical controversies surrounding the HIV/AIDS pandemic in the early twenty-first century. It covers both domestic and international policy. The course is divided into several parts. Part I, AIDS in the Courtroom, covers the major court cases related to HIV/AIDS in the United States. These cases demonstrate the social impact of AIDS– the effect of litigation on social institutions, constitutional law, and interpersonal relationships. Part II, Rights and Dignity, examines the role of international human rights, privacy, and discrimination. Part III, Policy, Politics, and Ethics, covers the most contentious debates of the HIV/AIDS epidemic, including testing, named reporting, and civil and criminal confinement. Part IV, Special Populations, covers the rights and obligations of groups at heightened risk or identified as having special responsibilities, including perpetrators and survivors of sexual assaults, HIV-infected health care workers, prenatal transmission of HIV, and injection drug users. The final Part, AIDS in the World, examines the central issues of HIV/AIDS in the world: the absence of political leadership, the international trade system which militates against access to affordable treatment in poor countries, and the ethics of international collaborative research. The AIDS pandemic has reached deeply into all major spheres of modern life–e.g., law, medicine, economics, and politics. The pandemic has transformed society and restructured ethical values. This course provides an account of the major themes of the pandemic during the last two decades and offers an analysis of contemporary and future policy.
3 credits, L. Gostin

MICB 515: Biological Threat Agents & Emerging Infectious Diseases
This beginning course will cover the basic principles of microbiology for graduate students with a wide variety of backgrounds who need a basic understanding of microbiology including bacteriology, virology, and immunology. Introductory lectures on these topics will precede a more in-depth review of biological threat agents and emerging infectious diseases. Issues of Public Policy and Advocacy with respect to biohazardous agents will also be addressed.
3 credits, L. Rosenthal & Staff

MICB 521: Biosurveillance: An Applied, Multidisciplinary Perspective
This course will cover managing biological threat through biosurveillance. A laboratory component will examine medical, animal, zoonoic, crop, and food surveillance - as well as detection of catastrophic bioevents. Students will participate in simulations of bioterrorist attacks to illustrate the use of surveillance to trigger response.
3 credits each, J. Collmann & J. Wilson

MICB 524: Emerging Diseases: The Past as Prologue
This course will study recent infectious disease outbreaks including Marburg virus in Angola 2005; Nipah virus in Bangladesh 2004, Monkeypox in the USA 2003, SARS in Hong Kong and Toronto 2003, West Nile Virus in the USA 1999-2006, Plague in India 2004, Hantavirus in the USA 1993, and the HIV/AIDS pandemic 1981-2006. Emphasis will be two-fold: (1) the interaction between the infectious disease pathogen and the human immune response, and (2) common public health and political themes in these outbreaks and how they will help prepare for future emerging (entirely novel) or re-emerging diseases (new within a given environment) diseases. Students will participate in a "tabletop exercise" on how to manage an emerging disease outbreak.
2 credits, D. Lucey

MICB 603: Science & Technology in the Global Arena
This course is an introduction to how science and technology affect foreign affairs, and how international affairs influence science and technology. It is the gateway course required of SFS juniors majoring in science, technology and international affairs (STIA), and College science majors taking the STIA certificate. It may also be taken by undergraduates and graduate students from anywhere in the university without special permission. It has no prerequisites, and is suitable both for the policy generalist and for students with backgrounds in science. The course uses examples drawn from environment, security, nuclear policy, information, communications, energy, homeland defense, health, and manufacturing technology, and explores issues of sustainability, scientific risk and uncertainty, the links of science and technology with economics and geopolitics, scientific advice to governments, and government support to research and innovation. It explores the role of technological innovation in increasing productivity and competitiveness, and in solving critical social problems.
3 credits, C. Weiss

MICB 604: Innovation Systems in Science, Technology & Health
This course focuses on science and technology policy. It will examine the science, technology and health innovation system, with a particular focus on public policy and the federal government's role in that system. It will review the foundations of innovation systems theory and organization, and the range of approaches to science and technology policy, and build toward a sophisticated understanding of these areas. Emphasis will also be placed on examining the organization and role of medical science innovation agencies, gaps in the health innovation economic model, and on policies that could help fill those gaps in health innovation. The mechanisms through which government obtains the science advice that is increasingly important to public policy will be discussed as well as the future of the science talent base. The class will review pending proposals for improving the government-related elements of the innovation system on an ongoing basis.
2 credits, W. Bonvillian

MICB 606: Public Policy for Scientists
This interdisciplinary course will provide introductory lectures in a variety of fields that pertain to biomedical science policy & advocacy. Lectures will cover relevant federal agencies, prominent science advocacy groups and techniques, principles of health economics, funding of research activities, the interaction of science & industry, as well as some controversial issues in science policy such as biodefense, stem cell research, and climate change. Students will be left with a multi-faceted understanding of the environment that shapes biomedical science policy and the scientists' role in this arena.
4 credits, R. Calderone & Staff

MICB 612: Immunology
The course will focus on the cells, organs and molecules of the immune system and how they contribute to discrimination of self from non-self. The paradigm used in the course will be the host response to infectious agents. Hypersensitivity, autoimmunity, graft rejection and tumor immunity will be considered as variations in the basic protective function of the immune system.
3 credits, M. Cole & M. Maric

MICB 614: Bacteriology & Mycology
The course will focus on principle human pathogenic bacteria and fungi. The host-pathogen relationship and antimicrobial therapy will be grounded in an understanding of the structure and physiology of medically-important prokaryotes and lower eukaryotes.
3 credits, M. Cole

MICB 619 Biology/Biochemistry of Viruses
This course will cover the general principles of virology. Topics will include: the effects of viruses on human health and disease; laboratory approaches to studying viruses; virus structure and mechanisms of replication; host responses to virus infection and viral counter-responses; virus engineering - including vaccine development and gene therapy; the role of virus ecology in emerging viral diseases. The focus will be primarily on viruses that affect human health.
3 credits, J. Casey

MICB 629: Mechanisms of Microbial Pathogenesis
A course designed to explore the varied ways pathogenic bacteria overcome natural host defense, to describe host responses to infection, and to discuss the network of interactions between pathogen and man at the molecular and cellular level.
3 credits, M. Cole

MICB 800 & 801: Seminar - Global Infectious Diseases
This graduate seminar is a unique combination of presentations by experts in biomedical sciences, policy, and social science that are united by key topics in global infectious diseases. The purpose of this seminar series is to provide a venue for the discussion of interdisciplinary research and development that acknowledges how the world has become a global system for the propagation of infectious disease.
2 credits, Staff

MICB 825: Social Propagation of Global Infectious Disease
This course will examine the hypothesis that the world has become a global system for the propagation of infectious disease. Beginning with an analysis of global trade and the spread of infectious disease, we will carefully study the economic, social and political conditions that have increased both the biological threat of, and human vulnerability to infectious disease throughout the world. In studies of the United States and Brazil, we will focus in detail on how the experience of poverty affects peoples? sense of risk, particularly for sexually transmitted diseases such as AIDS and cervical cancer. In studies of Haiti, Venezuela, and other countries, we will extend that analysis by examining how social inequality helps structure the global distribution of contracting and receiving treatment for infectious diseases such as tuberculosis, cholera and malaria in the developed and developing world. We will finish the course by examining how countries throughout the world have increased human vulnerability to infectious disease by undermining their public health infrastructures. After completing this course, students should better understand the complexity of global infectious disease as a biological, sociological, economic and political phenomenon.
2 credits, J. Collmann

MICB 852: Seminar: Microbiology & Immunology
Individual topics will vary depending on the expertise of each speaker. PhD students will attend all lectures and give seminar presentations covering progress of their work.
2 credits, R. Calderone

PHAR 534: Ethical Issues in Scientific Research
Discussions of ethical questions and dilemmas facing scientists today.
2 credits, S. Schwartz